Summer is in full swing, and we have research updates to share plus great ways to get involved in making a difference for the pancreatic cancer community. Our events continue to unite a community passionate about a cancer-free future and ensure that we can continue to fund research that drives us towards that goal. As our 25th year concludes, we remain steadfast in offering hope with the motto, “Never Give Up! Finding a cure is worth fighting for.” 

Dr. Timothy Donahue, Director of the UCLA Agi Hirshberg Center for Pancreatic Diseases and Garry Shandling Chair in Pancreatic Surgery at David Geffen School of Medicine at UCLA, has joined the Pancreatic Cancer Early Detection (PRECEDE) Consortium as a Principal Investigator. This Consortium brings together an international, multi-institutional collaborative group of experts with the aim to increase the 5-year survival rate from 10% to 50% in the next 10 years. With Dr. Donahue as a Principal Investigator, UCLA patients with a family history of pancreatic cancer or individuals who carry pathogenic genes will be able to enroll in the PRECEDE study for longitudinal follow up.

The PRECEDE Study is an observational long-term study of people with an increased risk for pancreatic cancer due to family history, a history of chronic pancreatitis or pancreatic cysts, or the presence of specific gene mutations linked to the disease. Study participants have blood work every 6 to 12 months with additional imaging collected for those in defined high-risk groups. This data-driven model integrates basic, translational and clinical research to greatly enhance our understanding of this disease and to drive early detection and prevention methods. The consortium aims to identify high-risk individuals, create an effective early detection test for pancreatic cancer, understand the risk factors, including susceptible genes, and develop a strategic pancreatic cancer prevention plan. As Dr. Donahue told us, “It is critical for high-risk individuals to join this important study in order to maximize identification and advance early detection of pancreatic cancer. Early detection would drastically change the trajectory of the disease and ultimately save thousands of lives.”

The Agi Hirshberg Center for Pancreatic Diseases and UCLA’s involvement in this study will expand the population of high-risk individuals involved and allow family members of patients to participate in deepening our knowledge of pancreatic cancer risk factors. We are hopeful that this collaborative, multi-institution project will make early detection and prevention for pancreatic cancer accessible for all so that we may see a marked increase in survival rates.

The National Comprehensive Cancer Network (NCCN) works to improve cancer care through their vast collection of Guidelines for Patients. The latest version of the Guidelines for Patients: Pancreatic Cancer, sponsored by the Hirshberg Foundation, provides information to help patients and their families navigate a pancreatic cancer diagnosis in an empowered and informed way.

The extensive guidelines include care options, treatment protocols, quotes from patients, advice for how to discuss treatment with doctors, and much more. The Guidelines for Patients are based on the recommendations in the NCCN Clinical Practice Guidelines in Oncology available to physicians. One of the most recent updates included for patients is the addition of a new first-line therapeutic option, liposomal irinotecan + 5-FU + leucovorin + oxaliplatin (known as NALIRIFOX). This new drug regime has shown promise in early-stage trials conducted by Dr. Zev Wainberg, a member of the UCLA Agi Hirshberg Center for Pancreatic Diseases, Professor of Medicine at UCLA and co-director of the UCLA GI Oncology Program.

Another highlight of the updated version is the recommendation that all individuals diagnosed with pancreatic cancer have genetic testing for a range of inherited mutations. The advice is to screen beyond just BRCA1 and BRCA2 to look at an array of mutations that can assist with treatment planning. There is also an expanded section on biomarker profiling for advanced and metastatic pancreatic cancer which can provide a molecular profile of small yet important features of the cancer. Biomarkers detect abnormal changes in cancer cells’ genes that occurred during your lifetime and may also help with treatment planning.

An update that we are excited to focus on is the whole-body approach to treatment that is emphasized in the latest Patient Guidelines. The Hirshberg Foundation has long advocated for a holistic method of treatment that takes into consideration the mind-body connection. The newest updates include details on supportive care that is recommended from the point of diagnosis. Treatment options have also taken on the best-practice of a more individualized approach based on individual and cancer specific characteristics.

The Hirshberg Foundation is proud to support this great work to ensure that all patients and caregivers receive the most up-to-date information to assist them through their cancer journey. The NCCN Guidelines for Patients booklet is available for digital download or to purchase through Amazon.

The UCLA Agi Hirshberg Center for Pancreatic Diseases continues to be one of the nation’s leading institutions for pancreatic cancer research, diagnosis, and treatment thanks to funding from the Hirshberg Foundation and our supporters. As we celebrated our 25 years of progress, we were elated to see the five-year survival rate for pancreatic cancer jump to 12 percent, a huge increase from the five-percent five-year survival rate of 1997, when we began. It is thanks to our fundraising events and our donors that we have been able to advance research, improve patient outcomes, and take these crucial steps towards a cancer-free future.

Each year, UCLA provides the Hirshberg Foundation with a detailed report of the progress that is possible thanks to our partnership. Below are updates on the important work taking place at UCLA.

UCLA Agi Hirshberg Center for Pancreatic Diseases

The Hirshberg Center is moving to a brand-new space on the top floor of 100 Medical Plaza on the UCLA campus. With state-of-the-art accommodations for patients and their loved ones, this larger space will be optimized to provide the uncompromising care the center is known for. Overseeing the development of this incredible space as the new Director of the UCLA Agi Hirshberg Center for Pancreatic Diseases, Dr. Timothy Donahue. The new space will unite the Integrated Practice Unit’s (IPU) team of specialists under one roof for enhanced collaboration among different departments and care areas. Currently all IPU pancreatic cancer patients undergo genetic testing, allowing the team to tailor treatment with new drugs that can target identified genetic alterations. Input from multiple disciplines on each patient’s case allows clinicians to deliver exceptional comprehensive care that is disease- and patient-specific. This new location will provide a beautiful healing space for patients to receive world-class care.

Nutrition for Safer Surgeries

Nutrition for Safer Surgeries is a new program at UCLA funded by the Hirshberg Foundation. Developed by Shelby Yaceczko, MS, RDN-AP, CNSC, CSSD, an advanced practice dietician at UCLA and speaker at our 17th Annual Hirshberg Symposium on Pancreatic Cancer, the program provides early nutrition assessment and intervention for any patient with a new or existing gastrointestinal cancer diagnosis, with a special focus on pancreatic cancer. Medical nutrition therapy services can prevent or correct nutritional deficiencies, enhance quality of life during cancer treatment, and minimize treatment’s side effects. Research has shown that perioperative nutrition evaluation and optimization are essential to the success of pancreatic cancer surgery and result in decreased morbidities and mortalities. A member of the IPU, Yaceczko consults with patients before surgery to improve surgical outcomes.

Robotic Surgery at UCLA

A 2016 Seed Grant recipient, Mark Girgis, MD, continues to advance robotic surgery at UCLA. Dr. Girgis, Director of Robotic Surgery and Assistant Professor of Surgery, David Geffen School of Medicine at UCLA, has helped robotic surgery gain momentum in the treatment of pancreatic disease. The minimally invasive technique improves long-term recovery prospects due to decreased healing time which allows patients to begin post-surgery chemotherapy sooner. The robotic surgery expertise of Dr. Girgis and his team enables them to expand patient populations eligible for surgery, regardless of complications and disease stage. The popularity of robotic surgery is on the rise with both patients and surgeons, and we are optimistic that this treatment option will improve patient care.

Clinical Trials for Treatment

Clinical trials are a crucial step in the development of effective therapies for pancreatic cancer. Many patients also benefit from participation in a clinical trial as part of the treatment. Patients seen through the Hirshberg Center’s IPU have access to an array of treatment options including the 19 clinical trials currently in progress at UCLA. Plus, the UC Pancreatic Cancer Consortium is currently running over 46 clinical trials focused on pancreatic cancer. These clinical trials not only help advance understanding of this disease, but they also offer patients and their families hope for better treatment options. The Hirshberg Center’s vast offerings of clinical trials for promising treatments put it at the forefront of pioneering translational research.

The Hirshberg Foundation’s partnership with UCLA has created a premiere pancreatic cancer center with cutting-edge research and world-class care that draws patients from across the country. Together we are making progress toward improved treatments, outcomes, and quality of life for patients with pancreatic cancer. We are hopeful that we can watch research progress accelerate towards a cancer-free future.

Read the full summary here →

We are seeing the seeds we planted 25 years ago with the creation of the Foundation come to full bloom. A pillar of our Foundation mission was “to create premier Pancreatic Cancer Center where all needs of pancreatic cancer patients can be met in one location with the most advanced treatment options.” That dream is now the UCLA Agi Hirshberg Center for Pancreatic Diseases and it is moving to a beautiful new space. We’ve had a celebratory sneak peek and look forward to sharing more when the Center opens this summer. This gorgeous new space will offer patients and loved ones world-class integrative care in one convenient location.

As we prepare for the new space, we are honored to welcome Dr. Timothy Donahue as the new Director of the UCLA Agi Hirshberg Center for Pancreatic Diseases. Dr. Donahue is the Garry Shandling Chair of Pancreatic Cancer Surgery, Chief of the Division of Surgical Oncology, and Program Director of the General Surgery Residency at UCLA. He is an expert in the treatment of pancreatic disease and oversees a NIH funded research program focused on pancreatic cancer. With Dr. Donahue as the Director and Dr. Joe Hines as Chair and Executive Medical Director of the Department of Surgery, our pancreatic cancer program at UCLA is in the most capable hands so that all patients can receive best in class care.

Taking the helm of our Scientific Advisory Board will be esteemed researcher, Dr. Miklos Sahin-Toth. Dr. Sahin-Toth has lead his namesake lab at UCLA since 2019. A world-renowned expert in the area of the pancreas disorders with a focus on genetic risk factors in chronic pancreatitis, Dr. Sahin-Toth brings a fresh perspective and talent as Chair of the board, particularly as we look towards the future. For the past 25 years we have invested in progress. Now, we look toward the next 25 years filled with hope for all that is to come.

These exciting changes are possible thanks to those equally invested in our motto, “Never Give Up: Finding a Cure is Worth Fighting For.”

Ten years ago, Julie Weiss finished her journey of 52 marathons in 52 weeks, in a quest to raise one million dollars for pancreatic cancer research and became known as the Marathon Goddess. On Sunday, March 19th, Weiss will be celebrated by pancreatic cancer survivors and supporters everywhere as she crosses the Los Angeles Marathon finish line yet again, and at the Hirshberg Foundation’s Purple People Party Cheer Station near Mile 21. The celebration will commemorate Weiss raising more than one million dollars for pancreatic cancer research over the past decade, and helping raise awareness about the disease that has the highest mortality rate of all major cancers.

MY BIGGEST FAN & INSPIRATION…

In 2010, following the death of her father to pancreatic cancer, Julie remained determined to make a difference, and running gave her a purpose. Just one week after he passed, she fulfilled their dream for her to qualify and run the Boston Marathon. He was, after all, her biggest fan. “I know he was there with me. He was the wind at my back and had the best seat in the house my heart after I ran the Boston Marathon in 2011,” Julie shared. From there, she decided to turn her passion into a purpose and embarked on an incredible endeavor to raise hope, money and awareness for pancreatic cancer. In time, Julie chose the name Marathon Goddess, but is quick to point out its true meaning that it is not about her, it’s a name that allows her to encourage others to embrace their passion and let it shine.

A $1 MILLION DOLLAR GOAL…

Since 2010, Julie has made many ties in the pancreatic cancer community. She has witnessed the ups and downs of statistics and gotten to know the faces and journeys of countless survivors whom she has run in honor of. Through the ups and downs, her focus hasn’t waivered: “When I began this journey, my objective was to raise a million dollars to find a cure for pancreatic cancer, the disease that took my father away from me, and to help others affected by this insidious disease,” said Weiss.“Julie set out to achieve a lofty goal, at the grass roots level, and never wavered in her commitment to see it through,” said Lisa Manheim, Executive Director of the Hirshberg Foundation. “In addition to being our partner in helping spotlight pancreatic cancer, the awareness and money she raised has helped fund much-needed research bringing us one step closer to finding a cure.” Throughout the years, Weiss has received support and donations from corporate sponsors and running organizations, however, the majority of her fundraising has come from individuals and families that have been impacted by the disease and those she has inspired through her running.

PHILANTHROPIST & AMBASSADOR…

As a marathon runner, author, philanthropist, ambassador and advocate, Weiss keeps busy by sharing enduring stories of hope, empowerment, loss and resilience from patients and families fighting for their lives and the lives of their loved ones. She has remained a fervent supporter of the Hirshberg Foundation throughout her journey, motivating fellow runners on the Hirshberg Training Team each year, running the LA Cancer Challenge 5K and receiving the Never Give Up Award, leading a team at Tour de Pier, and inspiring communities across the country to Never Give Up hope. She has been a spokesperson for the Hirshberg Foundation’s successful fundraising campaign, 52 Races for 52 Faces, a year-long, philanthropic crusade in which she competitively ran in marathons, half marathons, 10Ks and 5Ks in 52 cities throughout the U.S., and across the Pacific Ocean to shine a light on pancreatic cancer. The campaign started and ended with Weiss running the Los Angeles Marathon which also included the foundation’s signature Halloween fundraiser, the L.A. Cancer Challenge.

Through running, Weiss hopes to show the world that pancreatic cancer is much more than devastating statistics. There is a name and a face behind every survivor, and she is running for them. “Over a decade later, my mission to fight the good fight against pancreatic cancer has evolved to not only fundraise, but to be a voice for patients and to create awareness about the risks.” She added, “Although we have seen progress, more needs to be done, and together, we can find a cure. We got this!”

AN EXTRAORDINARY FINISH…

Throughout this extraordinary journey, Julie has shared enduring stories of hope, empowerment, loss and resilience from patients and families fighting for their lives and the lives of their loved ones. She has crossed over 1,000 finish lines, whether she was completing her 52 Races for 52 Faces campaign or her most recent 12 races in 12 months to raise awareness about the 5-year survival rate that has increased two years in a row. The stories she has helped share will never be forgotten and thanks to the one and only Marathon Goddess, we are $1 million dollars closer to a cure through research funding and patient programs. “Running with a purpose to fight the good fight against pancreatic cancer has become my mission; I will not stop until we have found a cure.” We look forward to cheering her on as she leaps across her 116th marathon finish line!