The Hirshberg Foundation for Pancreatic Cancer Research is proud to announce the following NIH awards, granted to UCLA Investigators who have been Seed Grant recipients from the Foundation.
The National Institutes of Health recognition represents a milestone for the Foundation’s mission of funding discoveries of the cause, cure and prevention of pancreatic cancer.
We extend our Congratulations to the following recipients:
NCI/NIH
Principle Investigator: U01 Nel, Meng, Zink, Donahue (Multi-PIs)
Dates: 11/01/15 – 10/31/20
Total Amount: $2,391,050
Description: UCLA Multifunctional Nanotherapeutics Platform for Treatment of Pancreas Cancer
Hirshberg Foundation
Principle Investigator: Meng
Dates: 11/15/15 – 11/14/16
Total Amount: $30,000
Description: Targeted delivery of irinotecan by the combined use of a transcytosis-inducing iRGD peptide and mesoporous silica nanoparticle for pancreatic cancer treatment
NSF grant
Principle Investigator: Li
Dates: 11/01/14 – 10/31/18
Total Amount: $100,000
Description: Thermal Drawing of Fibers with Individually Addressable Nanoelectrode Array for Cellular Electrophysiology
P&F grant
Principle Investigator: Meng
Dates: 08/01/16 – 07/31/17
Total Amount: $30,000
Description: Custom Design of Polyrotaxane Nanocarrier for CRISPR/Cas9 Delivery in DMD
NIH NIDDK P30 DK41301
Principle Investigator: Dr. Enrique Rozengurt
Dates: 11/30/2014 – 11/30/2019
Total Amount: $701,247/year
Description: CURE: Digestive Diseases Research Center
The major goals of this P30 Core Grant are to support multidisciplinary research, transfer of information and the award of seed grants. The CURE: Digestive Diseases Research Core Center Grant supports multiple Scientific Cores, a Pilot and Feasibility Program, the recruitment of a Named New Investigator and an array of Enrichment Activities regarding the function and diseases of the digestive system, including the pancreatic inflammation and cancer.
NIH NIDDK 5 R01 DK100405
Principle Investigator: Dr. Enrique Rozengurt
Dates: 06/01/2014-07/31/2018
Total Amount: $217,500/year
Description: PKD1 Signaling and Crosstalk Mechanisms in Intestinal Epithelial Cell Regulation
The major goals of this project are to: 1) Characterize the role of PKD1 signaling in intestinal epithelial cell proliferation in vivo and in stem cell-derived intestinal organoids. 2) Characterize crosstalk mechanisms between PKD1 and β-catenin signaling systems in intestinal epithelial cells. 3) Identify a novel mechanism of PKD1 regulation through PAK-mediated PKD1 phosphorylation at the N-terminal residue Ser203.
NIH NCI P01CA163200
Principle Investigator: Project 2: Dr. Enrique Rozengurt
Dates: 08/01/2012-07/31/2017
Total Amount: $132,279/year
Description: Chemoprevention of pancreatic cancer with anti-diabetic agents
The long term aim of this project is to characterize the chemo-preventive effects of metformin on the progression of PanINs using the conditional KrasG12D model subjected to standard or a high fat, high calorie diet (HFCD).
Department of Veteran Affairs IBX001473A
Principle Investigator: Dr. Enrique Rozengurt
Dates: 04/01/2012-03/31/2016
Total Amount: $150,000/year
Description: Calcium-Sensing Receptor Signaling In The Regulation Of Colonic Epithelial Cells
The major goals of this project are to: 1). Characterize the role of the CaSR in colon epithelial cell proliferation, differentiation, and cancer using a novel CaSR GI tract-specific knock-out mouse model. 2).Identify the signal transduction pathways that mediate the decrease in β-catenin phosphorylation at Ser-552 and Ser-675 in response to CaSR stimulation in colon-derived epithelial cells. 3) Characterize β-catenin sub-cellular distribution and transcriptional activity in response to CaSR stimulation in colon-derived epithelial cells.
NIH/NCI P01 CA163200-01A1 (Guido Eibl, MD)
Dates: 07/2012 – 07/2017
Total Costs: $7,500,000
Description: Targeting Diet-Induced Promotion of Kras-initiated Pancreatic Adenocarcinoma
The purpose of this study is to unravel the mechanisms by which obesity enhances pancreatic cancer development. In addition, strategies to prevent obesity-induced pancreatic cancer will be investigated.
Hirshberg Foundation for Pancreatic Research Sponsored Biobank
Principal Investigator: Dawson
Dates: 07/01/05 – present
Total Amount: $25,000 per annum
Description: UCLA Pancreatic Tissue Bank
This grant supports efforts to bank fresh pancreatic tumor tissues from surgical resection specimens and the creation of pancreatic tissue microarrays from archival FFPE material.
American Cancer Society RSG-12-083-01-TBG
Principal Investigator: Dawson
Dates: 01/2012 – 12/2015
Total Costs: $720,000
Description: Regulation and therapeutic targeting of Wnt signaling in pancreatic cancer
This award investigates mechanisms responsible for deregulated Wnt signaling in pancreatic cancer and their potential therapeutic implications.
David Geffen School of Medicine, UCLA Spitzer Grant
Principal Investigator: Dawson
Dates: 04/2015 – 3/2016
Total Costs: $30,000
Description: Global proteomic changes linked to the therapeutic efficacy of Wnt inhibitors in pancreatic cancer
This seed grant utilizes global proteomics approaches to more broadly define the biochemical changes associated with inhibitors of Wnt ligand secretion.
UCLA Department of Pathology Translational Research Grant
Principal Investigator: Dawson
Dates: 07/01/09 – 06/30/11
Total Amount: $8,000
Description: Evaluation of prognostic and predictive biomarkers in periampullary cancer by tissue microarray
This seed grant will create a periampullary neoplasm tissue microarray of 250 archival specimens with linked clinical information to be used for biomarker discovery and validation.
NIH/NCI P01 CA163200-01A1
Principal Investigator: Eibl
Dates: 07/2012 – 07/2017
Total Costs: $7,500,000
Description: Targeting Diet-Induced Promotion of Kras-initiated Pancreatic Adenocarcinoma
The purpose of this study is to unravel the mechanisms by which obesity enhances pancreatic cancer development. In addition, strategies to prevent obesity-induced pancreatic cancer will be investigated.
NIH/NIDDK P01 DK098108
Principal Investigator: Gukovskaya
Dates: 07/2014 – 06/2019
Total Costs: $7,500,000
Description: Organelle Disorders in Pancreatitis
This Program Project investigates pathogenic mechanisms of pancreatitis resulting from dysfunction of key acinar cell organelles.
NIH Reference #1 P01 AT003960-01A1
Principal Investigator: Dr. Vay Liang W. Go
Date of Grant: 09/30/2007 – 09/29/2012
Funding Institution: National Institutes of Health / National Center for Complementary and Alternative Medicine
Total Amount: $5,675,865
Description: UCLA Center for Excellence in Pancreatic Diseases
The goal of this Center for Excellence is to study phytonutrient mechanism of action in both inflammatory and proliferative diseases of the pancreas using molecular biology and metabolomics technology to investigate altered cellular functions.
NIH Reference #1 R01 CA123273-01A1
Principal Investigator: Dr. Anthony Heaney
Date of Grant: 10/01/2007 – 09/30/2012
Funding Institution: National Institutes of Health/National Cancer Institute
Total Amount: $1,250,000
Description: Refined Fructose Promotes Pancreatic Cell Growth
The goal of this application is to study the effects of diet rich in fructose on pancreatic cancer cells growth in vitro and in a tumor model.
NIH Reference #1 R01 CA122042-01A1
Principal Investigator: Dr. Guido Eibl
Date of Grant: 08/01/2007 – 05/31/2012
Funding Institution: National Institutes of Health / National Cancer Institute
Total Amount: $1,463,000
Description: The Role of n-3 Polyunsaturated Fatty Acids in Pancreatic Cancer
This project is designed to explore the efficacy of n-3 polyunsaturated fatty acids in therapy and prevention of pancreatic cancer using xenograft and transgenic animal models of the disease.
NIH Reference #1 R01 CA104627
Principal Investigator: Dr. Guido Eibl
Date of Grant: 02/01/2004 – 02/29/2009
Funding Institution: National Institutes of Health / National Cancer Institute
Total Amount: $1,100,000
Description: The Role of COX-2 and PPARY in Pancreatic Cancer
NIH Reference #R01 DK55003
Principal Investigator: Dr. Enrique Rozengurt
Date of Grant: 02/28/2008 – 05/30/12
Funding Institution: National Institutes of Health/ National Institute of Diabetes and Digestive And Kidney Diseases
Total Amount: $1,637,250
Description: Gastrointestinal Peptide Signaling through PKC/PKD
The major goals of this project are to characterize the activation of the PKC/PKD pathway and define the role of PKD in proliferative signal transduction in gastrointestinal (GI) cells.
NIH Reference #R01 DK56930
Principal Investigator: Dr. Enrique Rozengurt
Date of Grant: 05/30/2006 – 06/01/2011
Funding Institution: National Institutes of Health/ National Institute of Diabetes and Digestive And Kidney Diseases
Total Amount: $1,356,255
Description: GI Peptide signaling through tyrosine phosphorylation
The major goals of this project are to identify the role of GI peptide-induced tyrosine phosphorylation in signal transduction pathways implicated in cell migration and proliferation.
NIH Reference #P30 DK41301
Principal Investigator: Dr. Enrique Rozengurt
Date of Grant: 11/30/2009-11/30/2014
Funding Institution: National Institutes of Health/ National Institute of Diabetes and Digestive And Kidney Diseases
Total Amount: $4,725,000
Description: CURE: Digestive Diseases Research Center
The major goals of the P30 Core Grant are to support multidisciplinary research, transfer of information and the award of seed grants. The CURE: Digestive Diseases Research Core Center Grant supports multiple Scientific Cores, a Pilot and Feasibility Program, the recruitment of a Named New Investigator and an array of Enrichment Activities regarding the function and diseases of the digestive system, including the exocrine pancreas.
NIH Reference #M01 RR00425-33
Principal Investigator: Dr. Paul Lee
Date of Grant: 12/01/2006 – 11/30/2011
Funding Institution: National Institutes of Health/National Center for Research Resources
Total Amount: $732,095
Description: Biomedical Mass Spectrometry Core
NIH Reference #5 P60 AA11999
Principal Investigator: Dr. Hidekazu Tsukamoto
Date of Grant: 01/01/2009 – 12/31/2014
Funding Institution: National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism
Total Amount: $756,165
Description: USC-UCLA Southern California Research Center for ALPD and Cirrhosis: Alcohol Abuse and Pancreatic Necrosis
The long-term objective of this project is to determine the role of PKC isotypes in ethanol- induced sensitization of the inflammatory response using in vitro and in vivo models of the pancreas.
VA Merit Award
Recipient: Dr. Anna Gukovskaya
Date of Grant: 10/01/2006 – 09/30/2010
Funding Institution: Department of Veterans Affairs
Total Amount: $980,000
Description: NOX4, Protein Tyrosine Phosphatases, and Pancreatic Cancer Cell Survival
This project is designed to determine the effects of pancreatic cancer Nox4 in regulating protein tyrosine phosphatases; and the role of phosphatases in mediating pancreatic cancer cell survival.
VA Merit Award
Recipient: Dr. Steve Pandol
Date of Grant: 10/01/2007 – 09/30/2011
Funding Institution: Department of Veterans Affairs
Total Amount: $500,000
Description: Inflammation Medicates Necrosis in Pancreatitis
This project is to determine the effects of infiltrating neutrophils; NADPH oxidase; pharmacologic and genetic inhibition of PI 3kinase; and genetic inhibition of PTEN on pancreatic apoptosis, necrosis, PTEN/Akt system and its downstream pro-apoptic targets during experimental pancreatitis.
AACR Foundation
Recipient: Dr. David Dawson
Date of Grant: 07/01/2008 – 06/30/2010
Funding Institution: American Association of Cancer Research
Total Amount: $200,000
Description: Wnt signaling in pancreatic cancer
NIH Reference #R21 CA137292
Principal Investigator: Dr. Enrique Rozengurt
Date of Grant: 05/01/2009 – 04/30/2011
Funding Institution: National Institutes of Health/National Cancer Institute
Total Amount: $338,000
Description: Targeting crosstalk between insulin and Gq signaling systems in pancreatic cancer
The major goals of this project are to characterize a novel crosstalk between insulin receptor and Gq signaling in human pancreatic cancer cell lines. Furthermore, we will test whether metformin inhibits this crosstalk and offers a novel approach for the treatment of human pancreatic cancer, using tumor xenogafts in nude mice.
NIH Reference #1 R21 CA124609-01A1
Principal Investigator: Dr. Oscar Joe Hines
Date of Grant: 07/01/2007 – 06/30/2009
Funding Institution: National Institutes of Health/National Cancer Institute
Total Amount: $308,000
Description: The Role of CXCR2 in Pancreatic Cancer
The study investigates the role of CXCR2 in pancreatic cancer biology and angiogenesis as well as determine chemokine and receptor expression in human specimen.
NIH Reference #1 R01 CA119025-01
Principal Investigator: Dr. Anna Gukovskaya
Date of Grant: 07/01/2006 – 05/31/2010
Funding Institution: National Institutes of Health/National Cancer Institute
Total Amount: $300,000
Description: NADPH Oxidase and Pancreatic Cancer Cell Survival
This project is designed to determine the mechanisms of growth factors-induced NADPH oxidase activation in pancreatic cancer cells, as well as the role of this activation in promoting pancreatic cancer cell survival.
NIH Reference #1 R01 CA104627
Principal Investigator: Dr. Guido Eibl
Date of Grant: 02/01/2004 – 02/29/2009
Funding Institution: National Institutes of Health/National Cancer Institute
Total Amount: $1,100,000
Description: The Role of COX-2 and PPARY in Pancreatic Cancer
NIH Reference #R21 AA016840
Principal Investigator: Dr. Ilya Gukovsky
Date of Grant: 07/01/2008 – 06/30/2010
Funding Institution: National Institutes of Health/ National Institute of Diabetes and Digestive And Kidney Diseases
Total Amount: $275,000
Description: Alcoholic Chronic Pancreatitis Results from Dysregulated Immune Response
This project is designed to determine the mechanism and role of immune regulation by ethanol in mediating chronic alcoholic pancreatitis.
NIH Reference #1 R21 AA015781-01
Principle Investigator: Dr. Aurelia Lugea
Date of Grant: 07/10/2006 – 06/30/2008
Funding Institution: National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism
Total Amount: $275,000
Description: Plasminogen System and Alcoholic Pancreatitis
This project is designed to determine the effects and role of changes in the plasminogen system in alcohol-induced pancreatic disease. There is no scientific or budgetary overlap with any other active or pending project.
VA Merit Award
Recipient: Dr. Anna Gukovskaya
Date of Grant: 10/01/2006 – 09/30/2010
Funding Institution: Department of Veterans Affairs
Total Amount: $980,000
Description: NOX4, Protein Tyrosine Phosphatases, and Pancreatic Cancer Cell Survival
This project is designed to determine the effects of pancreatic cancer Nox4 in regulating protein tyrosine phosphatases; and the role of phosphatases in mediating pancreatic cancer cell survival.
AGA Foundation
Recipient: Dr. Olga Mareninova
Date of Grant: 07/01/2007 – 06/30/2010
Funding Institution: Designated Research Scholar Award in Pancreatitis
Total Amount: $250,000
Description: Bcl-2 Proteins Regulate Death Responses of Acute Pancreatitis
This project is designed to determine the mechanism and role of immune regulation by ethanol in mediating chronic alcoholic pancreatitis.
