Hirshberg Foundation for Pancreatic Cancer Research

Dedicated to advancing pancreatic cancer research and providing support to patients and their families.

Donate
  • ABOUT THE FOUNDATION
    • Agi’s Story
    • About Us →
      • Mission
      • Directors/Trustees
      • Scientific Advisory Board
      • How Our Journey Began
    • News →
      • Latest News
      • Research News
      • Foundation News
      • UCLA Activity Summary Reports
      • Newsletters
      • Press Room
    • Contact
  • PANCREATIC CANCER
    • About the Pancreas →
      • The Pancreas
      • Cancer Cells
      • Risk Factors
      • Symptoms
      • Diagnosis
      • Prognosis
      • Staging
      • Second Opinion
    • Treatment Options →
      • Surgery
      • Chemotherapy
      • Targeted Therapy
      • Radiation Therapy
      • Alternative Treatment Options
      • Clinical Trials
    • Supportive Care →
      • Obstructions
      • Pain Control
      • Nutrition
      • Cannabis
      • Palliative Care
    • Pancreatic Cancer Facts
    • Glossary of Terms
    • Frequently Asked Questions
  • RESEARCH
    • Seed Grant Program →
      • Seed Grant Recipients
      • Frequently Asked Questions
    • Seed Grant News
    • UCLA Program →
      • UCLA Center for Pancreatic Diseases
      • Basic Research
      • Translational Research
      • Sahin-Toth Laboratory
      • UCLA Pancreas Tissue Bank
      • UC Pancreatic Cancer Consortium
      • Simms/Mann Psychosocial →
        • Insights into Cancer
    • American Pancreatic Association
    • NIH Funded Projects
  • PATIENTS & CAREGIVERS
    • Patient Support
    • Where to Begin
    • Caregivers & Families
    • Symposium →
      • Symposium Presentations
    • Patient & Family Webinars
    • Genetic Counseling
    • Resources →
      • NCCN Guidelines for Patients
      • Patient Support Tools
      • Create Your Health Care Team
      • Patient Health Diaries
      • Support Groups
      • Financial Aid
  • HOW YOU CAN HELP
    • Planned Giving
    • Donor-Advised Funds
    • Event Calendar
    • Get Inspired
    • Fundraising Resources
    • November Awareness Month →
      • World Pancreatic Cancer Day
    • More Ways to Give →
      • You Can Help Funds
      • Host Your Own Event
      • Shop Online Store
      • Wedding Program
      • Volunteer
      • Car Program
  • SEARCH
Home / Research / Seed Grant Program / Seed Grant Recipients / Henry N. Higgs, PhD

Henry N. Higgs, PhD

Henry N. Higgs, PhD
Henry N. Higgs, PhD
Professor
Geisel School of Medicine at Dartmouth

PDAC cell-cell communication through membrane tubes: effects on cell survival and tumor progression

Overview

All cells in the body must communicate in order to function. Cancer cells have a particularly acute need to communicate for survival, and communication between cancer cells contributes to their ability to resist chemotherapy or radiation therapy. Several methods of cancer cell communication have been discovered, including intercellular membrane tubules (IMTs). IMTs are finger-like protrusions that can extend long distances and contact other cells. IMT connections are used to pass material or information between cells, aiding in cell survival. Imagine a garden hose connecting two fish tanks, with fish able to pass from one tank to the other through the hose. IMTs serve the purpose of the garden hose. My laboratory has found abundant IMTs in pancreatic cancer cells grown in isolation (after they have been taken out of a tumor), and we have preliminary evidence that IMTs are present in the intact tumor itself. We would use Hirshberg Foundation funding for several purposes. First, we would test whether IMT are present in tumors from a variety of pancreatic tumor patients. If IMTs are universally present in tumors, treatments abolishing IMTs might be effective on all pancreatic cancers. If IMTs are only present in some tumors, we can focus only on these tumors in a more personalized approach. Second, would figure out how IMTs are made and how they transmit information. If we can identify key molecules in these processes, we can design treatments for blocking them. Our goal is to help pancreatic cancer patients by developing new treatment methods.

Research

  • Seed Grant Program
    • Seed Grant Recipients
      • Katelyn T. Byrne, PhD
      • Julienne L. Carstens, PhD
      • Alicia K. Fleming Martinez, PhD
      • Mark Girgis, MD
      • Conan Kinsey, MD, PhD
      • Jacques Lux, PhD
      • Jimin Min, PhD
      • Somnath Pandey, PhD
      • Fredrik Ivar Thege, PhD
      • Liying Zhang, MD, PhD
  • Seed Grant News
  • UCLA Program
    • UCLA Center for Pancreatic Diseases
    • Basic Research
    • Translational Research
    • Sahin-Toth Laboratory
    • UCLA Pancreas Tissue Bank
    • UC Pancreatic Cancer Consortium
    • Psychosocial Care via Simms/Mann
      • Insights into Cancer
  • American Pancreatic Association (APA)
  • NIH Funded Projects

Patient Support Resources

from the comfort of your home


Our Webinar Library »

Never Give Up.
The journey continues with an end in sight.
Our Stories »
SUBSCRIBE
Our Free E-Newsletter
Sign up to receive information on breaking news, patient programs and upcoming events.
You can custom tailor your subscriptions and unsubscribe at any time.
  • How You Can Help
  • Make A Donation
  • Host an Event
  • Shop Online Store
  • Signature Events
  • L.A. Cancer Challenge
  • Tour De Pier
  • Hirshberg Training Team
  • More
  • News
  • Press
  • Contact

Stay Connected

Join Our E-newsletter

  • Legal and Privacy
  • Financial Information
  • Contact