- Director, Pancreatic Cancer Center, NYU Langone Medical Center
- Associate Director of Translational Oncology Program, Perlmutter Cancer Center
- Professor of Surgery and Pathology, NYU Langone Medical Center
Dr. Diane Simeone is the Laura and Isaac Perlmutter Professor of Surgery and Pathology at New York University and the Director of the Pancreatic Cancer Center, where she also serves as the Associate Director for Translational Research. An internationally renowned pancreatic surgeon and a researcher with a long-standing career focus on the treatment of pancreatic neoplasms, she has been continuously NIH-funded for the last 25 years investigating the molecular mechanisms driving pancreatic metastasis and the development of novel, more effective therapeutic strategies to treat pancreatic cancer patients. She has a large clinical practice taking care of patients with pancreatic neoplasms and those at elevated risk of the disease. She first discovered pancreatic cancer stem cells, identified ATDC as a novel oncogene in human cancers, and defined for the first time unique populations of cancer associated fibroblasts in pancreatic cancer. She has been an innovator in the development of therapeutic clinical trials for pancreatic cancer, and is the Principal Investigator of Precision Promise, a new adaptive platform clinical trial consortium focused on next-generation clinical trials for patients with pancreatic cancer. She also developed and leads the Precede Consortium, an international collaboration of 48 centers to study a large, longitudinal cohort of individuals at heritable risk for pancreatic cancer. She served as chair of the scientific and medical advisory board of the Pancreatic Cancer Action Network and has previously served as the president of the Society of University Surgeons and the American Pancreatic Association as well as on the National Cancer Institute’s Pancreatic Cancer Task Force. Dr. Simeone is a member of the Institute of Medicine of the National Academy of Sciences.